Date and time: February 12, Tuesday, 11:30 a.m.

Location: Carlos Santamaría Building, Room B14.

Speaker: Jean-Francois Moreau (University Hospital of Bordeaux)

Title: Aging as a metaphor of the importance of spatial organization in multicellular organisms

Date and time: February 19, Tuesday, 11:30 a.m.

Location: Carlos Santamaría Building, Room B14.

Speaker: Iñaki San Pedro (UPV/EHU)

Title: Degrees of Epistemic Opacity

Abstract:

The paper distinguishes two senses of “epistemic opacity” in computer simulations, namely a qualitative sense and a quantitative sense, and explores their relation to actual simulating and modelling practices.

From a qualitative point of view, the notion of “epistemic opacity“ in computer simulation seems to have the same significance and implications for any computer simulations. That is, from a qualitative point of view, computer simulations seem to be equally opaque —i.e. we open the black box, and find it (always) dark! In this sense “epistemic opacity” expresses the fact that when a computer simulation is performed there is an “epistemic leap” associated to it. This kind of epistemic leap is characteristic rather than of a specific model or simulation, of the fact that a simulation is performed.

On the other hand, “epistemic opacity” can also be approached from a quantitative point of view. The questions to be asked then are rather different, e.g. is the “epistemic leap” noted above always of the same size? or are all computer simulations equally opaque, i.e. when we open the back box and find it dark, is it always as dark? The paper argues that (from this quantitative point of view), computer simulations display degrees of “epistemic opacity” (with the limit of non-opacity set in analycity). I will not discuss here whether these degrees of “epistemic opacity” can be measured (i.e. exactly quantified), or attempt provide a method for doing that. I will claim nevertheless that actual degrees of “epistemic opacity” are tightly related to what we can call the “complexity of the computational process”, which is associated for instance to the particular design of the computing software at work, specific computer settings, or to hardware limitations. With this idea of complexity in mind, I will claim, the more complex a computational process is, the more (quantitatively) epistemically opaque will the simulation result.

I will note finally that a good deal of methodological decisions taken by scientist and modellers when performing computer simulations —i.e. typical tricks-of-the-trade such as parametrisation, use of expert knowledge, scaling, etc.—, which constitute an important part of current scientific practices in the field, are precisely aimed at reducing such complexity. I will conclude thus that actual scientific practices (or part of these, at least) in fact reduce (quantitative) “epistemic opacity.” This opens new and interesting questions such as whether actual scientific practices can manage to reduce “epistemic opacity” to the limit of analycity (thus eliminating “epistemic opacity” also in a qualitative sense), whether specific scientific practices can be said to reduce in some (qualitative) sense some of the uncertainties that computer simulations involve, or whether they have an impact on the reliability or confidence of specific computer simulations (possibly of the very same system).

Date and time: December 18, Tuesday, 11:30 a.m.

Location: Carlos Santamaría Building, Room B14.

Speaker: Charles Wolfe (Ghent University)

Title: “Philosophy of biology before biology”: a methodological provocation

Abstract:

Basing myself on work forthcoming in a volume entitled Philosophy of Biology before Biology (coedited w. C. Bognon-Küss), I argue for a conception I term ‘philosophy of biology before biology’, focusing on the theoretical ‘world’ or ‘context’ out of which the science ultimately called ‘biology’ emerged. This historico-philosophical approach to biology’s genesis is neither internalist study of biological doctrines, nor a reconstruction of the role philosophical concepts might have played in the constitution of biology as science; it looks more at the interplay between metaphysical and empirical issues. This study does not just have implications for understanding the relations between philosophy and biology in the mid- to late 18th century; it should also have an impact on our present understanding of philosophy of biology, given that it is necessarily conditioned by a very specific history and historiography (particularly evolution-centred). Further, ‘philosophy of biology before biology’ sheds a different light on our understanding of how biology as a science of life became unified.

Date and time: November 27, Tuesday, 11:30 a.m.

Location: Carlos Santamaría Building, Room B14.

Speaker: Nathaniel Barrett (“Mind-Brain Group,” Institute for Culture and Society, University of Navarra)

Title: The contrasts of feeling: Toward an integrated theory of affect and consciousness

Abstract: 

What is affect and how does it relate to other qualities of experience? Affect presents special challenges to explanation that are well known to investigators of pleasure and pain but normally do not enter into philosophical and scientific discussions of consciousness. In this paper I present an attempt to integrate affect and consciousness into a single theory based on the idea that affect is not a specially discriminated quality of experience but rather a function of the way the “feeling self” expands and contracts in relation to the qualities of feeling (Arnold 1960; Frederickson 1995). The key term for the elaboration of this thesis is contrast. Drawing from theories of the nonlinear dynamics of perceptual categorization (e.g. Freeman 1999; Spivey 2007) I propose that perceptual experience is constituted by complex contrasts specified by sensorimotor dynamics within a continually evolving, high-dimensional “contrast space” (cf. the “quality space” in Clark 1993; 2000). For this approach, affect pertains to “implicit” higher-order contrasts that obtain between successive contrast spaces of perceptual dynamics. That is, the affective tone of a perceptual feeling is not determined by perceptual qualities themselves but rather by the way in which these qualities are specified within an evolving contrast space that “expands” and “contracts.” I further suggest that the evolving contrast space of experience can be thought of as a dynamically constituted “feeling self.”

Date and time: December 11, Tuesday, 11:30 a.m.

Location: Carlos Santamaría Building, Room B14.

Speaker: Denis Walsh (University of Toronto)

Title: Summoning and Sedimentation: Concepts for an agent-centred evolutionary biology

Abstract:

I attempt to motivate an agent-centred ‘contact’ theory of evolution. I draw on debates in the philosophy of mind to illustrate a distinction between ‘foundationalist theories’ and ‘contact theories’. Traditional approaches to thought, perception, knowledge, linguistic meaning, are foundationalist. They start with the separation of an ‘inner’ mental realm from an outer realm, and posit mental ‘givens’ as the foundational elements. Foundationalist theories of the mind have well-known structural problems. Two, in particular, appear to be insuperable: (i) underdetermination (skepticism), and (ii) the missing agent. I argue that gene-centred evolutionary theory is also a foundationalist theory. It too suffers from the same problems. One prominent solution in the philosophy of mind is to adopt a wholly different kind of theory, a contact theory of the agent. I argue that a contact theory can have the same salutary consequences for the understanding of evolution as it does for mental phenomena.

Date and time: September 25, Tuesday, 11:30 a.m.

Location: Carlos Santamaría Building, Room B14.

Speaker: Gabriel Piedrafita, Wellcome Trust Sanger Institute (Cambridge, UK)

Title: Tissue-level cell-fate coordination underpins epithelial clone competition dynamics: theoretical modeling to open a conceptual discussion

Abstract: Epithelia are among the simplest mammalian tissues. Yet, little is known about how epithelial cells organize and orchestrate their fates (whether to divide, differentiate or die) to guarantee the turnover while preserving tissue homeostasis. Over a decade, theoretical models have been proposed according to which individual progenitor cell behavior would accommodate toautonomous, random fate choices, with remarkably good fits – at a statistical level – on lineage-tracing data from transgenic mice. It was my aim in this work to revisit these studies, and re-evaluate previous paradigms with an emphasis on bringing statistical-physics descriptions closer to the biological phenomenology at the cell level. By means of new experimental data and mathematical modeling, I will show how epithelial homeostasis can conform to simple rules where niche-sensing and collective cell-fate coordination play a predominant role. I would like to finish discussing how this domain of tissue-level communication would necessary constrain and impact on mutant clonal expansion, contributing to an internal control of tumourogenesis, letting the topic open for further debate.