IAS-Research Talk (Online) by Juan M. Loaiza: “Sandboxing: A Specification Hierarchy of Contexts of Constraint Interdependence”

Date: 09/06/2020, at 11:30

To participate, please contact: guglielmo.militello@ehu.eus


In this presentation I propose to bring interest to seemingly peripheral aspects of the theory of organisational closure based on constraint dependencies (Moreno & Mossio, 2015; Montévil & Mossio, 2015). In particular, I show how the theory can generate an alternative mapping of levels or hierarchies of organisation.The question I address is how contexts come about. I use Salthe’s distinction of compositional and specification hierarchies and show how the latter combined with some of the consequences of the constraint-based theory yields an interesting alternative. Compositional (or scalar) hierarchies are almost the default assumption across various disciplines (e.g. by adding parts we can go progressively from subatomic particles to populations, etc.). The alternative consists of an open-ended specification hierarchy of contexts which I call tentatively the “sandboxes” hierarchy (in reference to the metaphor of sandboxing in software development). By focusing on mapping contexts (the periphery), as a complement to the established theory of organisational closure (the centre), I point to possible integrative links across nomothetic and idiographic perspectives.   

IAS-Research Seminar (Online) by Leonardo Bich (EHU/UPV), “Multicellularity: realizing functional integration by organising the intercellular space”

Tuesday, 26/05/2020 at 11:30 (online, please contact guglielmo.militello@ehu.eus)


Paper available (open access) here:

The question addressed in this talk is how multicellular systems realise functionally integrated physiological entities by organising their intercellular space. 

From a perspective centred on physiology and integration, biological systems are often characterised as organised in such a way that they realise metabolic self-production and self-maintenance. The existence and activity of their components rely on the network they realise and on the continuous management of the exchange of matter and energy with their environment. One of the virtues of the organismic approach focused on organisation is that it can provide an understanding of how biological systems are functionally integrated into coherent wholes.

Organismic frameworks have been primarily developed by focusing on unicellular life. Multicellularity, however, presents additional challenges to our understanding of biological systems, related to how cells are capable to live together in higher-order entities, in such a way that some of their features and behaviours are constrained and controlled by the system they realise. Whereas most accounts of multicellularity focus on cell differentiation and increase in size as the main elements to understand biological systems at this level of organisation, these factors are insufficient to provide an understanding of how cells are physically and functionally integrated in a coherent system.

To address these issues, I present a new theoretical framework of multicellularity. The thesis is that one of the fundamental theoretical principles to understand multicellularity, which is missing or underdeveloped in current accounts, is the functional organisation of the intercellular space. From this perspective, the capability to be organised in space plays a central role in this context, as it enables (and allows to exploit all the implications of) cell differentiation and increase in size, and even specialised functions such as immunity. The extracellular matrix plays a crucial active role in this respect, together with the strategies employed by multicellular systems to exert control upon internal movement and communication. Finally, I show how the organisation of space is involved in some of the failures of multicellular organisation, such as aging and cancer.