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This paper addresses the ways in which Kant’s transcendental views concerning the intrinsic purposiveness of living organisms have been translated into naturalist territory by contemporary philosophy of biology. We critically evaluate the interpretive challenges posed by such endeavours and provide a tentative classification of the various approaches which have been proposed for applying Kant’s ideas today. We first delve into exegetical questions concerning the notions of mechanism and teleology, along with those of constitutive and regulative principles. We then distinguish three approaches to making Kant relevant today, each of which is characterized by a specific idea regarding what is useful about his perspective on teleology. We define those as heuristic, synthetic, and revisionist approaches respectively.