02/06/2020, at 16:00 To participate, please contact: firstname.lastname@example.org ABSTRACT: Host-associated microbiomes play a variety of important roles in host health and disease. Attempts to understand and make predictions about complex host-microbiome interactions have led many researchers to talk about microbiomes—especially human-associated ones—in terms of being … Continue reading
Date: 16/06/2020, at 11:30 To participate, please contact: email@example.com ABSTRACT: The last decades have seen the flourishing of accounts of evolutionary forces other than selection, many of which have been collected under the name of Extended Evolutionary Synthesis (ESS) (Laland … Continue reading
Date: 09/06/2020, at 11:30 To participate, please contact: firstname.lastname@example.org ABSTRACT: In this presentation I propose to bring interest to seemingly peripheral aspects of the theory of organisational closure based on constraint dependencies (Moreno & Mossio, 2015; Montévil & Mossio, 2015). … Continue reading
Tuesday, 26/05/2020 at 11:30 (online, please contact email@example.com)
Paper available (open access) here:
The question addressed in this talk is how multicellular systems realise functionally integrated physiological entities by organising their intercellular space.
From a perspective centred on physiology and integration, biological systems are often characterised as organised in such a way that they realise metabolic self-production and self-maintenance. The existence and activity of their components rely on the network they realise and on the continuous management of the exchange of matter and energy with their environment. One of the virtues of the organismic approach focused on organisation is that it can provide an understanding of how biological systems are functionally integrated into coherent wholes.
Organismic frameworks have been primarily developed by focusing on unicellular life. Multicellularity, however, presents additional challenges to our understanding of biological systems, related to how cells are capable to live together in higher-order entities, in such a way that some of their features and behaviours are constrained and controlled by the system they realise. Whereas most accounts of multicellularity focus on cell differentiation and increase in size as the main elements to understand biological systems at this level of organisation, these factors are insufficient to provide an understanding of how cells are physically and functionally integrated in a coherent system.
To address these issues, I present a new theoretical framework of multicellularity. The thesis is that one of the fundamental theoretical principles to understand multicellularity, which is missing or underdeveloped in current accounts, is the functional organisation of the intercellular space. From this perspective, the capability to be organised in space plays a central role in this context, as it enables (and allows to exploit all the implications of) cell differentiation and increase in size, and even specialised functions such as immunity. The extracellular matrix plays a crucial active role in this respect, together with the strategies employed by multicellular systems to exert control upon internal movement and communication. Finally, I show how the organisation of space is involved in some of the failures of multicellular organisation, such as aging and cancer.
- IAS Research Seminar, Kepa Ruiz-Mirazo’s talk, «The construction of biological ‘inter-identity’ as the outcome of a complex process of protocell development in prebiotic evolution»
- (English) IAS-Research (Online) Seminar by Alejandra Martinez and Hanne de Jaegher (UPV/EHU): «Pregnant agencies: movement and participation in maternal-fetal interactions»
- (English) IAS-Research (Online) Seminar by Kepa Ruiz-Mirazo (EHU/UPV) and Nino Lauber (EHU/UPV): «On the transition from self-organization to minimal metabolism»
- (English) Mark Canciani’s PhD defense
- (English) IAS-Talk by Çağlar Karaca (Kastamonu University): «Relational Basis of the Organism’s Self-organization»
- (English) IAS-Research Talk by Tim Klaassen (Tilburg University): «Enactivism and the Foundations of Ethics: Some Suggestions on How to Bring the Two Together»
- (English) IAS-Research Talk by Silvia de Cesare (Université de Genève): «The idea of organic «progress» and evolutionary theory: an epistemological perspective»
- (English) IAS-Research Talk by Marc Artiga (Universitat de València): “Do Bacteria Really Talk to Each Other?”
- (English) IAS-Research Seminar by Enara García and Iñigo Arandia-Romero (UPV/EHU): “La patología en la filosofía de la individuación de Gilbert Simondon”