La patología en la filosofía de la individuación de Gilbert Simondon Enara García and Iñigo Arandia-Romero (UPV/EHU) Tuesday 19 November 2019 at 11:30 (Centro Carlos Santamaria, B14) Language: Spanish Abstract En este trabajo, proponemos mirar en la filosofía de la … Continue reading
Autopoiesis in the Game of Life Manuel Heras-Escribano and Miguel Aguilera (UPV/EHU) Tuesday 3 December 2019 at 11:30 (Centro Carlos Santamaria, B14) Abstract In this talk, we will review a series of papers by Randall Beer. In these work he … Continue reading
Enactive and Simondonian reflections on placebo phenomena Iñigo Arandia-Romero (UPV/EHU) Tuesday 26 November 2019 at 11:30 (Centro Carlos Santamaria, B14) Abstract Placebo effects have played a key role in the history of medicine, and they are still nowadays extremely useful … Continue reading
Multicellularity: realizing functional integration by organising the intercellular space
Leonardo Bich (UPV/EHU)
Tuesday 17 December 2019 at 11:30 (Centro Carlos Santamaria, B14)
The question addressed in this talk is how multicellular systems realise functionally integrated physiological entities by organising their intercellular space.
From a perspective centred on physiology and integration, biological systems are often characterised as organised in such a way that they realise metabolic self-production and self-maintenance. The existence and activity of their components rely on the network they realise and on the continuous management of the exchange of matter and energy with their environment. One of the virtues of the organismic approach focused on organisation is that it can provide an understanding of how biological systems are functionally integrated into coherent wholes.
Organismic frameworks have been primarily developed by focusing on unicellular life. Multicellularity, however, presents additional challenges to our understanding of biological systems, related to how cells are capable to live together in higher-order entities, in such a way that some of their features and behaviours are constrained and controlled by the system they realise. Whereas most accounts of multicellularity focus on cell differentiation and increase in size as the main elements to understand biological systems at this level of organisation, these factors are insufficient to provide an understanding of how cells are physically and functionally integrated in a coherent system.
To address these issues, I present a new theoretical framework of multicellularity. The thesis is that one of the fundamental theoretical principles to understand multicellularity, which is missing or underdeveloped in current accounts, is the functional organisation of the intercellular space. From this perspective, the capability to be organised in space plays a central role in this context, as it enables (and allows to exploit all the implications of) cell differentiation and increase in size, and even specialised functions such as immunity. The extracellular matrix plays a crucial active role in this respect, together with the strategies employed by multicellular systems to exert control upon internal movement and communication. Finally, I show how the organisation of space is involved in some of the failures of multicellular organisation, such as aging and cancer.
- IAS-Research Seminar by Arantza Etxeberria (UPV/EHU): “Revisiting the “organism/environment interaction” category”
- Reading Group on Simondon
- IAS-Research Seminar by Guglielmo Militello: Motility Control of Symbionts and Organelles by the Eukaryotic Cell
- IAS-Research Talk by Matthew Egbert (University of Auckland): Autonomous & Self-Sensitive Organisms, Behaviours and Ecological Systems
- Ias-Research Talk by Neda Maki (University of Toronto): “Autism in the Canadian Arctic”
- Evolution and the embodied mind: The biological roots of 4E cognition
- IAS-Research Talk by Miguel A. Sepúlveda-Pedro (Université de Montréal): “Opening the ecological dimension of the enactive approach: Umwelt, normativity, and form”
- IAS-Research talk by Maria Jimena Clavel (University of St. Andrews): “Embodying imagination “
- Research Workshop Philosophy of Biology and Cognitive Sciences